Daily Note

Mutations in papillary thyroid carcinoma

Category Subtype/Details Genetic Alterations Notes / Associations Histologic Subtype Associations Tall Cell PTC - BRAF p.V600E (80%) -...

Lung adenocarcinoma with target therapy associated mutations

HGPIN versus AIP versus IDC-P

Feature HGPIN AIP IDC-P Definition Proliferation of atypical epithelial cells within preexisting ducts/acini without invasive features....

Hemosiderotic Fibrolipomatous Tumor (HFLT)

Karyotype Near-diploid karyotype with balanced or unbalanced t(1;10)(p22-p31;q24-q25) , loss of material from 3p , and amplification of...

Undifferentiated looking kidney tumor

MPNST features

A duct filled with solid arrangement of cells in breast

Basaloid nests of tumor in H&N region

Steroid cell tumor malignant potential

Reference: Fadare O, Fard EV, Bhargava R, Desouki MM, Hanley KZ, Ip PPC, Li JJX, Lu B, Medeiros F, Ng JHY, Parkash V, Pinto A, Quick CM,...

STIC vs STIL vs p53 signature

Numan, T. A. (2023). Atlas of gynecologic pathology . Numan, T. A. (2023). Atlas of gynecologic pathology .

Pseudomyogenic EHE

Picture credit from WHO classification of tumor and Dr. Ren Dong, MD, UC Irvine

MEST vs metanephric stromal tumor vs renomedullary interstitial cell tumor

Crushed blue cell nodule in lung

Comparing the lymphoid tissue (first image) , the tumor cells are crushed and more spindly. This study examined CD5 expression in thymic...

Mesothelial lesions in gyn pathology

Adenofibroma in uterus is not recognized anymore

The current criteria for adenosarcoma is phyllodiform cleft-like or dilated glands (rigid cysts) lined by benign endometrial or...

Papillary adenoma versus papillary RCC in Kidney

Trisomy 7 and 17 and loss of Y chromosome; + for CK7, AMACR

High grade spindle cell tumor in the arm differentials

A case of HGPIN with foci suspicious for cancer

lesson: sneaky glands with prominent nucleoli with adjacent big glands show similar cytomorphology; you might want to consider everything...

A case of challenging prostate adenocarcinoma

No nucleoli but relative rigid lumen with some dirty secretion Case credit: Dong Ren, MD UC Irvine

Molecular testings of endometrial cancer: talk from Dr. Anca Oniscu from BAGP teaching session

Only POLE shows clearly favorable survival compared to copy-number high (TP53) group FIGO 2023 for endometrial cancer Aggressive...