Case 16

A 64 year-old male was found to have a 14 cm retroperitoneal mass encasing the right kidney and a 4.3 cm mass in the right kidney parenchyma.

The right kidney mass:

1. What is the diagnosis by morphology? A panel of stains below if needed:

   A. Clear cell renal cell carcinoma

   B: Angiomyolipoma

   C: Paraganglioma

   D: Chromophobe renal cell carcinoma

   E: Clear cell papillary renal cell tumor

   F: Oncocytoma

IHC

• PAX8
• Pan-keratin
• CAIX
• AMACA

See All Options

You can vote for more than one answer.

Answer

2. The perirenal fat section is shown above. Could you guess the stain?

   A: MDM2

   B: P53

   C: CDK4

   D: Pan-keratin

   E: P16

   F: S100

   
   

Answer

Reference:

Wai, K.C.; Strohl, M.P.; van Zante, A.; Ha, P.K. Molecular Diagnostics in Human Papillomavirus-Related Head and Neck Squamous Cell Carcinoma. Cells 2020, 9, 500. https://doi.org/10.3390/cells9020500 

Li J, Wilkerson ML, Deng FM, Liu H. The Application and Pitfalls of Immunohistochemical Markers in Challenging Diagnosis of Genitourinary Pathology. Arch Pathol Lab Med. 2024 Jan 1;148(1):13-32. doi: 10.5858/arpa.2022-0493-RA. PMID: 37074862.

https://www.pathologyoutlines.com/topic/softtissuewdliposarcoma.html

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD