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Case 33

Jan 24

A young female was found to have a cervical lesion and the biopsy is shown as follows:


1.What's the morphology impression and what stains you would like to order?


IHC

  • p16

  • Pan-keratin

  • PAX-8

  • ER, PR


  1. The tumors were diffusely positive for p16, negative for all the marker above, except for small amount of claudin 4. IN1 and BRG1 were retained. What's your favored diagnosis?


A. HPV-related endocervical adenocarcinoma

B. HPV-related small cell carcinoma

C. Lymphoma

D. poorly differentiated neoplasm/carcinoma

E. Undifferentiated carcinoma


Answer to question 1 and 2


Reference: Saad RS, Mashhour M, Noftech-Mozes S, Ismiil N, Dubé V, Ghorab Z, Faragalla H, Khalifa MA. P16INK4a expression in undifferentiated carcinoma of the uterus does not exclude its endometrial origin. Int J Gynecol Pathol. 2012 Jan;31(1):57-65. doi: 10.1097/PGP.0b013e318223118a. PMID: 22123724.


Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD

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