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Case 36

Jan 26

A 70-year-old female with a prior diagnosis of malignant thigh mass and presented with a lesion in the brain, here is the CSF specimen cell block.


Hint: No IHC will help 100% diagnosis this entity in soft tissue world; However, S100, C-KIT, and neuroendocrine markers are starters before molecular.
Hint: No IHC will help 100% diagnosis this entity in soft tissue world; However, S100, C-KIT, and neuroendocrine markers are starters before molecular.

  1. What is the molecular alteration for this entity?

    A: EWSR-FLI1

    B: STAT6-NAB2

    C: FUS-DDIT3

    D: FUS-CREB

    E: TAF15-NR4A3


Answer

Case credit: UCSD Pathology

Author: Wangpan Shi

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