Case 37

A 50-year-old male with a 6.7 cm thigh mass and here is the biopsy.

1. What stains you would like to order?

   
   

IHC

• Keratin
• S100
• SOX10
• CD34

See All Options

You can vote for more than one answer.

2. The tumors are classically positive for S100 however, in this form it's negative, but the tumor is positive for SOX11. What's the molecular for this entity?

   A: FUS-CREB

   B: EWSR1-ERG

   C: BCOR rearrangement

   D: GLI rearrangement

   E: FUS-DDIT3

Answer

References: https://tumourclassification.iarc.who.int/chaptercontent/33/16

Xu S, Dong Y, Huo Z, Yu L, Xue J, Wang G, Duan Y. SOX11: a potentially useful marker in surgical pathology: a systematic analysis of SOX11 expression in epithelial and non-epithelial tumours. Histopathology. 2019 Feb;74(3):391-405. doi: 10.1111/his.13757. Epub 2018 Dec 2. PMID: 30221780.

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD