Case 42

A 56-year-old female with a 6.3 cm infiltrative mass in the right breast.

1.What is the nuclear grading of this lesion?

Nuclear grading

• grade 1
• grade 2
• grade 3

Table from CAP protocol; https://documents.cap.org/protocols/Breast.DCIS.Bx_1.0.1.0.REL_CAPCP.pdf?_gl=1*8743mk*_ga*MTI2Mjc4MjcwMS4xNzE5NjcwNTUw*_ga_97ZFJSQQ0X*MTczODI1MzYwMC4yNy4wLjE3MzgyNTM2MDEuMC4wLjA.

Answer

2. What is the Nottingham Histologic Score (Elston-Ellis modification of Bloom-Richardson grading system) of the part below:

   
   

   

   
   

   

   
   

   

   
   

   

   
   

   

   
   

Answer

References: https://tumourclassification.iarc.who.int/chaptercontent/32/18

https://documents.cap.org/protocols/Breast.DCIS.Bx_1.0.1.0.REL_CAPCP.pdf?_gl=1*8743mk*_ga*MTI2Mjc4MjcwMS4xNzE5NjcwNTUw*_ga_97ZFJSQQ0X*MTczODI1MzYwMC4yNy4wLjE3MzgyNTM2MDEuMC4wLjA.

Ping, Z., Xia, Y., Shen, T. et al. A microscopic landscape of the invasive breast cancer genome. Sci Rep 6, 27545 (2016). https://doi.org/10.1038/srep27545

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD