A 70-year-old women who presented with abnormal uterine bleeding and she underwent an endometrial biopsy. The tumor is strong and diffusely positive for p16.
What's your diagnosis of big category?
A: High grade serous carcinoma
B: High grade endometroid carcinoma
C: Sarcoma
D: Endometrial stromal sarcoma
E: Leiomyosarcoma
F: Poorly differentiated endocervical adenocarcinoma
G: Diffuse large B cell lymphoma
Answer
Croce S, Ducoulombier A, Ribeiro A, Lesluyes T, Noel JC, Amant F, Guillou L, Stoeckle E, Devouassoux-Shisheboran M, Penel N, Floquet A, Arnould L, Guyon F, Mishellany F, Chakiba C, Cuppens T, Zikan M, Leroux A, Frouin E, Farre I, Genestie C, Valo I, MacGrogan G, Chibon F. Genome profiling is an efficient tool to avoid the STUMP classification of uterine smooth muscle lesions: a comprehensive array-genomic hybridization analysis of 77 tumors. Mod Pathol. 2018 May;31(5):816-828. doi: 10.1038/modpathol.2017.185. Epub 2018 Jan 12. PMID: 29327710.
Case credit: UCSD Pathology
Author: Wangpan Jackson Shi, MD
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