A 56 year old male with history of long term smoking presented with hematuria. Here is the TURBT specimen:



What IHC you would like to see in this tumor?
IHC
GATA3
CK20, CK7
p63
PAX8
Answer
Based on the IHC profile and mophology features, what diagnosis you would favor?
A: Clear cell adenocarcinoma
B: Metastatic carcinoma with clear cell features
C: Clear cell sarcoma
D: Urothelial Carcinoma with clear cell features
Answer
Case credit: UCSD Pathology
Author: Wangpan Shi, MD
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