Case 59

A 87-year-old female with abnormal uterine bleeding and she was found to have a large cervical mass.

1. What's the possible diagnosis?

   A: High grade carcinoma

   B: Lymphoma

   C: Sarcoma-leiomyosarcoma

   D: Endometrial stromal sarcoma

   E: IMT

   F: Ewing sarcoma

   G: EWSR-non ETS sarcomas

   H: Myoepithelioma

   I: EMC

   J: SMARCA4 deficient sarcoma

   
   

IHC

• Pan-keratin
• SOX10
• INI1 (SMARCB1)
• BRG1 (SMARCA4)

See All Options

1. The tumors are positive for BCOR and focal positivity for Cyclin D1, negative for CD10, SMA, S100, ER.

   What's the favored diagnosis?

   A: HGESS with YWHAE rearrangement

   B: HGESS with BCOR fusion

   C: HGESS with BCOR ITD

   D: HGESS, NOS

   
   

Answer:

References: https://tumourclassification.iarc.who.int/chaptercontent/34/246

Case credit: https://qp.91360.com/10074.html?lang=en

Author: Wangpan Shi, MD