Case 63

A 45 year old female with weight loss and abdominal pain, here is the gastric biopsy.

1.Poorly cohesive carcinomas (PCCs) account for what percentage of gastric cancers (GCs), and in which patient population are higher frequencies reported?

A. 20–54% of GCs, with higher frequencies in Japanese patients

B. 10–20% of GCs, with higher frequencies in European patients

C. 5–10% of GCs, with higher frequencies in North American patients

D. 60–80% of GCs, with higher frequencies in African patients

Answer

2.What does poorly cohesive carcinoma belong to in the TCGA molecular classification?

A: EBV-positive

B: MSI- unstable

C: Gnomically stable

D: Chromosomal unstable

Answer

References: https://tumourclassification.iarc.who.int/chaptercontent/31/29

Case credit: UCSD Pathology

Author: Wangpan Jackson Shi, MD