A 40-year-old female with a cervical mass presented with abnormal uterine bleeding. An endometrial biopsy as well as endocervical curettage were sent for pathology. Below is the EMB sample:
1.What is the diagnosis by morphology?
A: FIGO3 endometrioid carcinoma
B: Clear cell carcinoma
C: Endometrioid carcinoma with mucinous differentiation
D: Invasive stratified mucin producing carcinoma
E: Squamous cell carcinoma
F: Microgandular hyperplasia
Answer
Here is the section from the ECC specimen:
A panel of immunostains showed that the tumor cells are diffusely positive for P16, negative for ER. What's the final diagnosis?
A: FIGO3 endometrioid carcinoma
B: Clear cell carcinoma
C: Endometrioid carcinoma with mucinous differentiation
D: Invasive stratified mucin producing carcinoma
E: Squamous cell carcinoma
F: Microgandular hyperplasia
Answer
Case credit: UCSD Pathology
Author: Wangpan Jackson Shi, MD
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