This study examined CD5 expression in thymic carcinoma and its relationship to the lymphoid stroma. All thymic carcinoma cases expressed CD5, with CD5+ lymphocytes present in the stroma. CD5+ tumor areas were predominantly adjacent to the lymphoid stroma, and CD5 expression was lower in tumor cells than in lymphocytes. While p53 and Bcl-2 levels were elevated in thymic carcinoma compared to normal thymic epithelial cells (TECs), they were similar between CD5+ and CD5− areas. E-cadherin expression was comparable to normal TECs and consistent across CD5+ and CD5− regions. In contrast, both Ki-67 index and mitotic activity were significantly higher in thymic carcinoma than in normal TECs and were elevated in CD5+ areas compared to CD5− areas.
Reference: Hosaka N, Ohe C, Miyasaka C, Nakano Y, Sakaida N, Uemura Y, Saito Y, Ikehara S, Tsubura A, Takahashi H. The role of CD5 expression in thymic carcinoma: possible mechanism for interaction with CD5+ lymphoid stroma (microenvironment). Histopathology. 2016 Feb;68(3):450-5. doi: 10.1111/his.12742. Epub 2015 Jul 16. PMID: 26018940.
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