Karyotype | Near-diploid karyotype with balanced or unbalanced t(1;10)(p22-p31;q24-q25), loss of material from 3p, and amplification of 3p11-p12. |
t(1;10) Translocation | Does not result in a fusion transcript but consistently targets TGFBR3 (1p22) and OGA (10q24), leading to transcriptional upregulation of FGF8 and NPM3. |
Frequency of t(1;10) in HFLT | Found in up to 85% of cases. |
3p Amplification | Contains VGLL3 and CHMP2B, both showing increased expression. |
Pathogenetic Link Between Tumors | Similar cytogenetic abnormalities (TGFBR3 and OGA rearrangement, VGLL3 amplification) are shared among HFLT, PHAT, and MIFS, suggesting a common molecular pathway. |
BRAF Fusions | Present in some Myxoinflammatory Fibroblastic Sarcomas (MIFS) but not detected in HFLT. |
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